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Vacation Rentals near Lake Keowee Marina

150 Keowee Marina Dr, Seneca, South Carolina 29672-4725
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    Seneca is popular with travelers just like you. Don’t let them get your perfect place first—book today!
    All 181 Rentals in Seneca
    Summer's Way - 9 Bedroom Family Getaway1 / 30
    4.1 miles from Lake Keowee Marina
    9 Bedrooms, 8 Bathrooms, Sleeps 18 Quick View
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    Tranquil Lakefront Setting near Clemson SC1 / 16
    (10)Very good
    3.9 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 6 Quick View
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    Private setting close to Clemson University1 / 20
    (38)Excellent
    4.7 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 8 Quick View
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    Beautiful Lakefront Rental on Lake Keowee near Clemson. Pets welcome!1 / 14
    (87)Very good
    3.2 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 16 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 16
    Tee House on BEAUTIFUL Lake Keowee1 / 25
    (31)Excellent
    0.5 miles from Lake Keowee Marina
    4 Bedrooms, 4 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 4 Bathrooms, Sleeps 8
    Great Location! Close to town & amenities, just 10 miles from Clemson University1 / 30
    (109)Excellent
    1.3 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 12 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 12
    LAKE FRONT RETREAT! Steps Away from Swimming, Boating, Kayaking & Relaxing! �1 / 30
    (49)Excellent
    4.7 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 4 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 4
    Keowee Family Retreat1 / 30
    (72)Excellent
    2.1 miles from Lake Keowee Marina
    6 Bedrooms, 6 Bathrooms, Sleeps 23 Quick View
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    Seneca, South Carolina
    Rental Home - 6 Bedrooms, 6 Bathrooms, Sleeps 23
    Beautiful lakefront property on Lake Keowee, minutes from Clemson University!1 / 30
    (15)Excellent
    1.8 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 8
    Easy access lake front W/ beach, waterfront patio and boat ramp1 / 30
    (139)Excellent
    5.3 miles from Lake Keowee Marina
    6 Bedrooms, 5 Bathrooms, Sleeps 14 Quick View
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    Seneca, South Carolina
    Rental Home - 6 Bedrooms, 5 Bathrooms, Sleeps 14
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    Home on Beautiful Lake Keowee Now w/ WiFi1 / 30
    (16)Excellent
    1.8 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 9 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 9
    Large Family Lake House Minutes from Clemson and Seneca. Sleeps 14 people!1 / 23
    (14)Excellent
    7.8 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 15 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 15
    Family getaway on lake near Clemson campus1 / 25
    5.2 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 12 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 12
    Family friendly Lake Keowee water front home in great location for Clemson games1 / 30
    (17)Excellent
    1.5 miles from Lake Keowee Marina
    4 Bedrooms, 5 Bathrooms, Sleeps 12 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 5 Bathrooms, Sleeps 12
    Charming Keowee Lakeview Home - Near Clemson1 / 23
    4.7 miles from Lake Keowee Marina
    3 Bedrooms, 3 Bathrooms, Sleeps 7 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 3 Bathrooms, Sleeps 7
    Fall fun at the cabin! Convenient to Lake Keowee and Clemson1 / 22
    (98)Very good
    2.1 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 2 Bathrooms, Sleeps 8
    **Beautiful Lake Keowee Home Sleeps 15 ** GET AWAY AND RELAX!!1 / 30
    (63)Excellent
    4.0 miles from Lake Keowee Marina
    5 Bedrooms, 4 Bathrooms, Sleeps 5 Quick View
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    Seneca, South Carolina
    Rental Home - 5 Bedrooms, 4 Bathrooms, Sleeps 5
    Lake Keowee Condo with Great Views! Near Clemson, Marina, Hiking, Waterfalls!1 / 23
    (37)Excellent
    0.6 miles from Lake Keowee Marina
    2 Bedrooms, 3 Bathrooms, Sleeps 6 Quick View
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    Seneca, South Carolina
    Condo/Apartment - 2 Bedrooms, 3 Bathrooms, Sleeps 6
    Panoramic Views, Best Location on Keowee, 150' of shoreline, 10 min. to Clemson1 / 27
    (81)Excellent
    1.9 miles from Lake Keowee Marina
    2 Bedrooms, 2 Bathrooms, Sleeps 4 Quick View
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    Seneca, South Carolina
    Rental Home - 2 Bedrooms, 2 Bathrooms, Sleeps 4
    Comfortably Designed Lake Keowee Waterfront, Minutes to Clemson- In Seneca1 / 30
    (40)Excellent
    0.5 miles from Lake Keowee Marina
    5 Bedrooms, 4 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 5 Bedrooms, 4 Bathrooms, Sleeps 10
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    Lake Keowee lakefront 4 bedroom 3 bath home dock, patio and fire pit.1 / 30
    (30)Very good
    4.5 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 10
    Pristine views from Lakefront Home1 / 30
    (108)Excellent
    3.0 miles from Lake Keowee Marina
    4 Bedrooms, 4 Bathrooms, Sleeps 4 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 4 Bathrooms, Sleeps 4
    4/3BB,3 acres, covered Dock, 2 Lrg.Covered Decks, 4.9 rating, $2400 mon/winter1 / 30
    (609)Excellent
    4.0 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 11 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 11
    Lake front home with dock, boat ramp and pool. Minutes from downtown Clemson.1 / 30
    (43)Very good
    0.2 miles from Lake Keowee Marina
    5 Bedrooms, 3 Bathrooms, Sleeps 5 Quick View
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    Seneca, South Carolina
    Rental Home - 5 Bedrooms, 3 Bathrooms, Sleeps 5
    Paradise on Lake Keowee1 / 20
    (28)Excellent
    1.1 miles from Lake Keowee Marina
    4 Bedrooms, 4 Bathrooms, Sleeps 7 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 4 Bathrooms, Sleeps 7
    *Relaxed Cancel.Policy,Clemson,Lake Hartwell A Frame1 / 30
    (14)Very good
    4.6 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 2 Bathrooms, Sleeps 8
    �Lake Front Private Retreat 15 min to Clemson� Dock, Pdle boat, Kayaks, canoe1 / 30
    (162)Excellent
    7.3 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 2 Bathrooms, Sleeps 10
    Clemson Game Ready! 5 Miles To Death Valley On Lake Hartwell. NO CLEANING FEES!1 / 22
    (27)Excellent
    7.6 miles from Lake Keowee Marina
    3 Bedrooms, 3 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 3 Bathrooms, Sleeps 8
    Dujardins waterfront lake Keowee home, with double dock on a deep, wide cove...1 / 27
    (47)Excellent
    2.7 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 12 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 12
    Newer Lake Keowee Cottage - the best luxury rental on the lake1 / 19
    (5)Excellent
    3.8 miles from Lake Keowee Marina
    5 Bedrooms, 4 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 5 Bedrooms, 4 Bathrooms, Sleeps 10
    Lake Hartwell lakefront home near Clemson University baseball and other events1 / 30
    (9)Excellent
    7.3 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 2 Bathrooms, Sleeps 8
    Lake Hartwell - 15 mins to Clemson, Tubes, Skis, Wakeboards. Floats and Memories1 / 30
    (83)Excellent
    7.4 miles from Lake Keowee Marina
    5 Bedrooms, 5 Bathrooms, Sleeps 14 Quick View
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    Seneca, South Carolina
    Rental Home - 5 Bedrooms, 5 Bathrooms, Sleeps 14
    The Cutt, Relaxing, private, lake front paradise on stunning Lake Keowee in SC.1 / 30
    (23)Excellent
    4.5 miles from Lake Keowee Marina
    4 Bedrooms, 4 Bathrooms, Sleeps 12 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 4 Bathrooms, Sleeps 12
    Furnished apartment perfect for short term stay!1 / 8
    3.5 miles from Lake Keowee Marina
    1 Bedroom, 1 Bathroom, Sleeps 4 Quick View
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    Seneca, South Carolina
    Condo/Apartment - 1 Bedroom, 1 Bathroom, Sleeps 4
    Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson1 / 29
    (71)Excellent
    1.6 miles from Lake Keowee Marina
    4 Bedrooms, 4 Bathrooms, Sleeps 15 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 4 Bathrooms, Sleeps 15
    Clemson Football! 3 miles to campus, call for long stay, Pet friendly!1 / 21
    (30)Excellent
    2.8 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 6 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 2 Bathrooms, Sleeps 6
    Seneca Serenity. The Ultimate Getaway on Lake Keowee!!1 / 30
    (37)Excellent
    1.8 miles from Lake Keowee Marina
    7 Bedrooms, 5 Bathrooms, Sleeps 24 Quick View
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    Seneca, South Carolina
    Rental Home - 7 Bedrooms, 5 Bathrooms, Sleeps 24
    Large family home with dock on Lake Keowee!1 / 30
    (77)Excellent
    4.5 miles from Lake Keowee Marina
    7 Bedrooms, 8 Bathrooms, Sleeps 7 Quick View
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    Seneca, South Carolina
    Rental Home - 7 Bedrooms, 8 Bathrooms, Sleeps 7
    " Estate on the Lake"! 7 BR/7 BA( 6 Suites)Over 8,400 Square Feet! Private Pool!1 / 30
    (166)Very good
    2.4 miles from Lake Keowee Marina
    7 Bedrooms, 7 Bathrooms, Sleeps 18 Quick View
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    Seneca, South Carolina
    Rental Home - 7 Bedrooms, 7 Bathrooms, Sleeps 18
    Great for Clemson Home Game Weekends1 / 26
    (44)Excellent
    4.7 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 6 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 2 Bathrooms, Sleeps 6
    Spring Specials- Its Warm Enjoy Weekends $250/Night1 / 30
    (43)Very good
    2.4 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 10
    WINTER DEALS! Clemson/Lake Keowee Vacation Home for Family, Friends and Football1 / 30
    (69)Excellent
    1.4 miles from Lake Keowee Marina
    3 Bedrooms, 3 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 3 Bathrooms, Sleeps 10
    Lake Keowee Lakefront Home W/ Private Boat Ramp-Great Rates1 / 30
    4.3 miles from Lake Keowee Marina
    3 Bedrooms, 3 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 3 Bathrooms, Sleeps 10
    Clemson Basecamp Events1 / 21
    (44)Excellent
    4.7 miles from Lake Keowee Marina
    3 Bedrooms, 2 Bathrooms, Sleeps 6 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 2 Bathrooms, Sleeps 6
    MEMORIAL DAY WEEKEND just OPENED UP!!!!! Book your stay now!1 / 30
    (110)Excellent
    1.4 miles from Lake Keowee Marina
    4 Bedrooms, 4 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 4 Bathrooms, Sleeps 10
    LAKE KEOWEE LAKEVIEW CABIN WITH DOCK CLOSE TO CLEMSON1 / 24
    (20)Excellent
    4.7 miles from Lake Keowee Marina
    3 Bedrooms, 3 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 3 Bedrooms, 3 Bathrooms, Sleeps 8
    500 FT OF DEEP WATER FRONTAGE ON THE BEAUTIFUL EMRALD COLOR WATER OF LAKE KEOWEE1 / 30
    (81)Excellent
    1.9 miles from Lake Keowee Marina
    4 Bedrooms, 3 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 3 Bathrooms, Sleeps 10
    Luxury on Lake Keowee - Clemson Graduation May 20231 / 30
    (55)Excellent
    1.9 miles from Lake Keowee Marina
    8 Bedrooms, 6 Bathrooms, Sleeps 24 Quick View
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    Seneca, South Carolina
    Rental Home - 8 Bedrooms, 6 Bathrooms, Sleeps 24
    7mi to Clemson Custom Family Luxury Lakehome Game room+ Shuffleboard + Fire Pit1 / 30
    (50)Excellent
    0.4 miles from Lake Keowee Marina
    4 Bedrooms, 6 Bathrooms, Sleeps 10 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 6 Bathrooms, Sleeps 10
    Secluded Seneca/Clemson Lake Hartwell Waterfront, 3 miles to CU1 / 19
    (134)Excellent
    5.2 miles from Lake Keowee Marina
    4 Bedrooms, 6 Bathrooms, Sleeps 8 Quick View
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    Seneca, South Carolina
    Rental Home - 4 Bedrooms, 6 Bathrooms, Sleeps 8
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