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A Prime Position in Midtown Manhattan. The Wyndham Midtown 45 at New York City is a serene, sophisticated oasis in the heart of Manhattan. Located on 45th Street between 2nd and 3rd Avenues, The Wyndham Midtown 45 at NYC is within walking distance of many of New York City’s major attractions such as Grand Central Station and the United Nations, as well as Park, Madison and Fifth Avenues. It offers easy access to Times Square, the Theater District, the SoHo & Tribecca neighborhoods, and Wall Street.