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Albuquerque is roughly divided into 4 quadrants by Central Ave (also known as " Old Route 66") running East to West ,and The Santa Fe Railroad, which runs North to South. You'll hear the quadrants referenced as Northeast (NE), Northwest (NW), Southeast (SE), and Southwest (SW). Within these quadrants, and sometimes straddling the boundaries, are Albuquerque's neighborhoods.
The interstates, I-25 and I-40, have somewhat reshaped the layout of Albuquerque and only vaguely correspond to the quadrant layout still used by the residents. For further orientation, see the article on Getting Around.
For maps, check out the following: