Melrose is one of many antebellum mansions located in and around Natchez, but it is the only one operated by the National Park Service.  The park gives hourly tours of the Greek revival-style mansion, which includes much of the home's original furniture and architecture.  Tours also emphasize the role slaves played in building and maintaining the house from its construction in 1841 to the end of the Civil War.  There are other other original buildings on the grounds, including the slaves quarters which feature an exhibit about slave life in antebellum Natchez.  

 The Park Service also maintains a house in downtown Natchez once owned by barber and businessman William Johnson, one of the few free black men in Mississippi before the Civil War.