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Right in the Inner Harbor area you have the Harborplace pavilions which offer some typical "touristy" shopping with souvenir type items. Also, The Gallery right across from the Inner Harbor Pavilions has three levels of stores.
You can take the water taxi, cab or a walk to Fell's Point and Harbor East where you will find more unique one of a kind shops and boutiques. There are antique stores, and other interesting stores on the waterfront.
The most unique and funky stores are in Mt. Vernon just up Charles St. from the Inner Harbore area. Pretty cool clothing and apparel stores and art galleries. There is quite a range of cost.
Interesting in antiquing? Baltimore's Antique Row is home to many store that contain rare, unique and improbable wonders.