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Transportation by taxi or rental car is conveniently easy from Greenville-Spartanburg International Airport, which is located between the two cities, in Greer, South Carolina, right next to Interstate 85. Airport Express offers taxi and limousine service and is located the the airport on Airport Drive.
Taxi fare to town can range from $15 to $30, depending on your destination. Taxi services in the city are numerous, so you should have no trouble procuring one, if needed, once you're there. Hotels often work with conjunction with taxi services, so it may be a good idea to ask your receptionist to recommend one. The best way to obtain a taxi in Greenville is to make a call. Use the above link to help you decide.
Alamo, Avis, Budget, Hertz, and Thrifty Car Rentals are also located at the airport, so pick your favorite and get going. Whether you are driving your own vehicle or renting, a car is the way to go, as it affords you the freedom to travel some of the areas back roads, where you'll see beauty and interest you won't find in the city. Hertz has opened a local edition rental facility in Greenville, which offers car rental for about town business or pleasure.
It's always best to reserve a rental car before arriving, as this usually gets you the best price. You can do this through your travel agent, or online.