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There is truly no better time to be in Iowa City than a football Saturday in the autumn. The weather is often spectacular and the fall leaves can be breathtaking. September and October are the best months, in my opinion. Late April through early June is also a recommended time to visit Iowa City. Flowers will be in bloom and you are likely to have reasonably temperate weather. Avoid visiting Iowa City in the heart of summer (oppressive heat and humidity) or the dead of winter (frigid cold).