You can choose to travel by land, air or sea.

Sea:    A modern ferry sails from Marco Island to Key West. seasonally,  December through April.  Check the website for scheduled departures - http://www.seakeywest.com/rates.html   Ticketing and boarding begin at 7am with departure at 8:30 am.  It is a three hour and a half trip in each direction. Adults pay $86 for one way and $146 for a round trip. Children up to 12 years pay $58 one way and $81 round trip. Seniors receive a round trip reduced fare of $136..

Air:    The main airport is Southwest Florida International Airport (RSW), located in south Fort Myers, about a 30-minute drive to Naples, with many direct connections between U.S. cities as well as several direct international routes between the airport and Canada, Germany and Puerto Rico. There is a regional airline, Silver Airways, that provides regular scheduled service from Southwest Florida International (RSW) Airport in Fort Myers to Key West.  

Land:    A car is a necessity to get to the area's natural attractions such as  Everglades National Park's Gulf Coast entrance in Everglades City. Drivers will mainly use Interstate I-75 north-south in the Naples area. The section of I-75 known as Alligator Alley goes east-west betweenNaples and Fort Lauderdale. U.S. 41, known as the Tamiami Trail, runs north-south through most of Naples and then east-west between Naples and Miami. The Tamiami Trail is the more scenic route through the Everglades.