Getting around Mexico city is fairly simple even though it is a large place.  Most of the neighborhoods are very walkable, set up in a grid pattern with a large square at the center.  The city's streets and main thoroughfares are often broken up by huge traffic circles centered by large monuments, making it harder to become lost. 

Mexico City is also a mix of New York City and Los Angeles. Although a car is very important and useful, there are some regions where public transportation and walking can workout. It is important to know that in some parts of the west side of Mexico City (Santa Fe,) which is upper class zones, a car is very important and to move around because the public transportation is much slower and walking is not a very safe nor comfortable way. Walking works, but only in very large sections. Not everywhere, it is safe to walk around and it might take a lot to get to your destination. Taxis are ver useful and not expensive. Renting a car might come in handy, due to it's freedom and cheap parking, but get ready to try one of the cities with the worst drivers and the police corruption. Public transportation is extremely cheap, but not always clean or safe and take for granted that you will be much more slower to get to your destination.

Although the city's streets are easy to navigate, remember, Street signs are in Spanish, but international signage is used, so brush up on Spanish and international traffic symbols. There are several alternatives to driving in the city.   Taxis are plentiful as are the public buses.  The Metro, Mexico City's subway system, is also an excellent and inexpensive way to get around.