Mission House is located in Bodden Town, Cayman's first capital, and is approximately 20 minutes drive from George Town. Head east on Shamrock Road continuing onto Bodden Town Road, pasing the Bodden Town Post Office. Turn left on to Gun Square Road, the entrance is marked by two large cannons. Mission House is at the end of the road.

If approach from the Eastend Districts, pass Webster Memorial Church in Bodden Town and turn ringt onto Gun Square Road.