According to forum posts, a well-recommended itinerary for Northern Argentina includes exploring Salta, Jujuy, and Tucumán. Travelers have suggested spending 1-2 days in Tucumán to visit the city and nearby Tafí del Valle, followed by 3 days in Cafayate for city tours and winery visits. The Quebrada de las Conchas and Garganta del Diablo are also essential stops.

For many users, the journey continues with a drive through the Quebrada de las Flechas route to Cachi, exploring the Los Cardones National Park and Valle de las Cuevas, and spending a day in Salta city. The itinerary can include a trip to the Viaducto La Polvorilla/Tren de las Nubes and Salinas Grandes, followed by visits to Purmamarca, Tilcara, Humahuaca, and the Cerro de los Catorce Colores.

Some travelers said that for those with limited driving options, using tours strategically as transportation to move between destinations while enjoying guided stops along the way is a beneficial strategy. This approach allows for a deeper exploration without the stress of driving in tricky terrain.

According to forum posts, among the must-see places in Salta and its surrounding areas are the Quebrada de Humahuaca, which includes the towns of Purmamarca, Tilcara, and Humahuaca. Purmamarca is famous for the Cerro de los Siete Colores, and Tilcara is known for its Pucará, an ancient fortress.

Travelers have mentioned the importance of visiting Salta's city center, which boasts well-preserved colonial architecture and vibrant local culture. The MAAM museum and the historic San Francisco Church are highly recommended. Additionally, the Tren a las Nubes offers a unique way to experience the local landscape and culture.

For natural attractions, the Salinas Grandes salt flats are a highlight, often compared to Bolivia's Salar de Uyuni. The drive through Cuesta del Obispo, offering panoramic views and a route through the Parque Nacional Los Cardones, is also a must-do for visitors to the region.