We went here before a Sabres game recently, as it's close by the First Niagara Center. This place came highly recommended by the locals, and I can see why!
Though the upstairs was very busy, with a 45 minute wait, we seated ourselves downstairs, where you are served fast food style; placing your order at a counter and waiting for your name to be called.
The bartenders were incredibly friendly, the beer was cold and cheap, and the food was yummy; a perfect starter to a game night. The atmosphere was also a major reason I enjoyed this place; everyone was having a great time, no pretentiousness!
I will definitely return to the Pearl St Grill and Brewery!