I had the time of my life last week at the Last Supperclub. Located in the heart of Pioneer Sq, and next door to other clubs 'Trinity' and 'Heavens', this one wins hands-down as the best. The line-ups continue to have the best DJ acts-they have international recognition and tear up the dance floor.
I go about once every six weeks, and have a great time every time. The bartenders are professional and the doormen don't have attitude (but maybe this is because I'm female). All in all, if you like house, progressive and trance, come here. If you like hip hop and rap, stay away, at least on Fridays.
I live in Capitol Hill, near The Paramount, and it's about a $7 cab ride to the club, fyi.