This is a nice drive compared to most highway driving I have done. The water is quite lovely. The main issue with this drive is that it is slow, long and if you're stuck behind a slow driver there aren't many opportunities to pass. I recommend doing it at least once just to get the real experience of the Keys. If you're only going down to Key West it's worth stopping at a restaurant in one of the upper keys just to see get more a feel for the Florida Keys.
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