I have been stay in Vista Grande Osaka for 5 days. It located at the centre of tourist attraction. Walk about 20 mins to Namba JR station and 10 mins to MTR station. Many good restaurant located around hotel together with shops and you can go shopping anytime. Most of the shop in Japan closed at 8:00 but you can still some open a bit later around the hotel.
Room is big compared with general hotel room in Japan. Price is reasonable and Staff in hotel is very nice.
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