This cathedral is a good way or orient yourself in Antigua. It is at the "top" of the main square. Once you know how to find this, everything else will fall into place. Antigua seems like a maze at first, but by finding the cathedral (and perhaps the cross on the hill), you can find everything else.
The ruins (entrance is on the side street - not the front) are beautiful in the daytime. The best photos are probably when the sun is out in full to limit shadows, but honestly, any time is lovely and you can choose your angles. Once inside the ruins, make an immediate right to descend by stairs into the South crypt. It is an ominous set of rooms and passages where you can explore a bit. The security guard on the main level can tell you more about the history if you speak Spanish.
At night, the best photos can be taken outside the front of the main church by standing at the edge of the park. You may just have to wait for the cars to pass every now and then. The lighting is beautiful and it is still safe in Antigua after dark. Just be smart about where you walk and how you carry your belongings.
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