Centro Cultural Palacio La Moneda is a relatively new contemporary art space located on the south side of the Palacio de la Moneda, a block north of O’Higgins near the La Moneda metro stop. It is entirely underground and the glass ceiling provides a diffuse natural light source for the main canyon of the facility. When my wife and I visited there was a yoga class going on in the main area and combined with the hanging artwork, cafes, shops around the perimeter it created a really pleasant atmosphere. It was quiet and tranquil like a museum without being stuffy and oppressive. Since its free in the mornings and it makes for a nice break on your walking tour of Santiago, duck in for quick snack or coffee. And there are separate gifts shops for each price point.
The galleries branch off from the main area and depending the exhibit you may or may not care to visit them. Best to check what’s showing ahead of time on their website at http://www.ccplm.cl/sitio/
But note that the English language version and the Spanish language version give different opening hours. In English, it did not seem that the Centro was open on Saturday! But the Spanish has it correct and it is indeed open on weekends.
Anyway, on our visit we really liked the main exhibits. Combined with the overall design of the space, the nice combination of services and the convenient location I would recommend this to anyway taking a day tour of Santiago.