The Hanania is located in the northeast quadrant of Old Damascus (the Christian Quarter), in a cul de sac alley off Hanania Street. Hanania Street is a mostly-pedestrian street that runs north from the eastern end of Straight Street adjacent to Bab Sharqi (the historic Eastern gate to Old Damascus). If you arrive in the wee hours of the morning, as I did, your taxi will drop you outside Bab Sharqi gate. Go through the ancient Roman triple arch, take the first right, and walk almost all the way to Anania Church to find the alley to the hotel on the left. The darkness may be a bit daunting, but the route is safe at all hours.
The hotel setting is very quiet--no street noise intrudes from the busy highway outside the walls. The hotel has 9 rooms which range in size from tiny to 2-room suite. All are clean and simply furnished, and all open to an inner courtyard that displays numerous paintings and sculptures. The staff speak English well; the front office is staffed around the clock. I stayed for two weeks (and my wife, traveling for business, for a full month). We found the staff to be courteous, friendly, and helpful at all times. From the Hanania, it is easy to walk to---and get delightfully lost in --- all parts of Old Damascus. The Hanania is not a fancy luxury hotel, but it is clean, safe, and comfortable. My wife, who is by no means an adventure traveler, was comfortable to stay there alone after I departed.
We have no reservations about giving the Hanania a strong recommendation.