Although the Basilica Cistern was on our list of "things to see," we happened upon it one day when the Blue Mosque was closed for prayers and the Hagia Sofia had a long line.
It is a hauntingly beautiful place, much larger than I had anticipated. The pictures give you a sense of what you will see, but to experience it in person is entirely another story.
One suggestion: wear good, non-slip walking shoes. I am in the midst of recovering from a broken leg and still walk with a single crutch/stick. The stairs were a bit tricky but I took my time and made it down (and then back up) okay. The floors were a bit moist/slippery, particularly around the far end/Medusa columns. Other that paying some close attention to this, I see no reason why it can't be on the site list for someone that has some mobility issues.
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