We had the misfortune of experiencing Omonia Square due to booking a room at the Achillion Hotel through American Airlines Vacations. We were first warned about the danger of the square by our taxi driver from the airport who told us to stay out of the area after dark as "it is the most dangerous square in Athens." Then, as he was dropping us off at our hotel two blocks from the square, said that he would not be able to drive us back to the airport for our flight home as he had offered 20 minutes before.
When we left the hotel later that evening to get dinner (It's hard to avoid going out after dark when sunset is at 4:30pm in November!), we saw homeless people sleeping on the sidewalks and punks running around the square. I felt a little safer walking around with my husband, but did notice that women did not venture out in the area alone after dark.
The best had to be when we went to Santorini for a couple of days, and even there were warned to stay out of Omonia Square. Apparently the area is well known all over Greece for it's sketchiness.
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