Like all the other reviews, my partner and I loved out stay here. The hostess was very welcoming, and our room was spacious, airy, beautifully appointed, and had view of the Duomo. The bed and pillows were the most comfortable we have ever had in our 3 weeks abroad. We also had access to coffee, a huge selection of teas, biscotti, and fruit 24hrs a day.
As many have commented, the B&B is on the Duomo's doorstep, and is a 10 min walk to Santa Maria Novella train station (convenient for travelling to/from Rome and Cinque Terre).
If anything, i would recommend notifying the B&B of estimated arrival time. We had no trouble checking in because we arrived during the day, but we have heard the door bell buzzing incessantly in the very early hours of the morning, possibly from guests who wanted to check-in before reception opened.
But overall, i would not hesitate recommending this B&B to family and friends.