My wife and I visited Venice for three days on our 25th wedding anniversary. The location is great. We took the river bus from Marco Polo airport to the 'San Stae' stop which takes around 45 minutes and costs 15 Euros single or 27:50 euros for a 30 day return (June 2019). The hotel is about 2 minutes walk from the San Stae stop so even with heavy suitcases it would be easy (Venice is not somewhere you want to drag big cases around as there are lots of bridges to climb up!).
We arrived very early (11:00am) but the staff allowed us to drop our bags so we could wander around the city until it was ready (about 13:30). Our room was in their 'dependency' hotel about 8 metres from the main hotel and access is through a separate locked door that you buzz to get access to (answered very quickly every time we went back). Staff were very friendly and carried my wifes' bag all the way to our room. The room included a small ante/entrance room with a wardrobe, safe, small TV, chaise longue and tea/coffee making facilities with a separate door to the bedroom. The bedroom (also with Smart TV) was reasonably sized with a fridge bar, and small table. The room was quiet despite overlooking the street and only being on the first floor so we got a good nights' sleep. The hotel had also added some chocolates for my wife on our anniversary (had the request in advance and pay of course but they had wrapped them and left them on the bed which was a nice touch).
In the morning we had to walk out the entrance and back into the main hotel and there was a small breakfast area with outside courtyard which was cool even in the hot June 2019 morning. There was ample choice, including continental, cereals, etc and the tea/coffee was made to order.
I would definitely recommend this hotel, I rarely give a 5 rating but had no hesitation for this hotel.

The best kept hotel secret in Venice. We found it originally in the RS Venice book and then did our own research to be sure it was okay - WOW the reviews were correct!

Great location - 10 minutes walk to the Rialto Bridge, 20 to St. Mark's Square, and an easy ride on the Alilauna orange line to San Stae if you are coming from the Airport. Authentic neighborhood that feels very safe.

We were in room 45 in the Annex, which is on the first floor, and it was absolutely perfect. Very comfortable, spacious, and with a great bathroom. No elevator, which wasn't a problem for us.

Staff is wonderful and so helpful, breakfast a delightful smorgasbord of delicious delicacies. Eggs, cereal, bacon, pastries, fruits, cheese and the list goes on. Perfect place to retreat back to each night - we will definitely stay here when we are back in Venice!