Great location in s Marco area. Quiet location away from crowd noise, but only a 4 minute walk to St. Marks square. Front desk staff is very knowledgeable and helpful. Venice is not easy to navigate but the staff gives great directions and suggestions.. Our room was very clean and spacious, much larger than we expected (it is hard to convert meters to feet and get an accurate idea of the space). Very comfortable king sized bed with sitting area. Breakfast was very good.
Caution- Getting to the hotel with heavy suitcases is tricky if you take the water bus/ground transport from the airport due to bridges, canals, blocked walkways,and an occasional dead end. It is expensive but very well worth paying for a water taxi to deliver you straight to the front door. Besides, the scenery and views are great on the ride in.
We would definitely stay at the Duodo hotel again!

My husband and I stayed here for our Honeymoon years ago and recently returned on a trip with my parents. As we remembered, the rooms were decorated with rich Venetian décor with tall ceilings and lovely marble bathrooms. Housekeeping did an excellent job of cleaning the rooms and restocking the toiletries during our stay. And the hotel’s location is fantastic, halfway between the Rialto and San Marco Square but tucked away from all the noise. The hotel has made a couple of changes in the last few years. For starters, the bathtubs are now shower/tub combos which was a nice change. Unfortunately, breakfast has completely gone downhill. It’s been moved into a cramped room with few good food options including undercooked soft boiled eggs. It was so cramped that we were forced to share a table with strangers and guests arriving after us had no where to sit. Breakfast was ample and served in a large room during our previous stay so this was disappointed. We chose to eat breakfast elsewhere during the rest of our stay. We also had issues with the Air Conditioning – it would shut off after only a few minutes of running and we kept having to restart it. This feature caused the room to get too hot overnight. It was unseasonably warm during our visit, but leaving the windows open wasn’t an option since we got attacked by mosquitos. Other than the inadequate breakfast and the Air conditioning issues, we still enjoyed our time at this hotel.

After spending time in a less-than-great hotel in Rome we were pleasantly surprised by the elegant beauty of the Duodo Palace Hotel. We were given a spacious room on the top floor looking out over several domes and statues (room 402).The beds were comfortable and the hotel was spotlessly clean. The breakfasts were wonderful and the staff friendly. I don't think we would have enjoyed Venice as much as we did if we'd stayed near the Grand Canal which is busier and lots more touristy. I would strongly suggest you not try to find it on your own, though, since it's tucked away into the middle of the island and would have been almost impossible to find the first time. We hired a great guy to take us and our luggage to the hotel - best $25 we could have spent! You could also be taken to the hotel by small boat or gondola since it sits on a quiet canal. The Duodo Palace is near a quiet square with a beautiful theater (wish I could have gotten tickets to an event there) and excellent restaurants and shops. Also, there are many corridors that allow you to easily get around the island. It felt like a private neighborhood. My only complaint would be that we noticed that the tours and water taxis cost us more when booked by the hotel's desk staff than if we'd arranged them ourselves. I asked why we had to pay a cash fee (from $12 to $26) up front when booking and we were told it was part of the cost of the event. That proved to be untrue, as we could tell when we had to pay the full posted tour/taxi/whatever cost later. I didn't make an issue of it thinking that I just didn't understand them due to the language barrier, but found out from other guests that they didn't have to pay the fees. I loved the hotel and would stay there again, but I would not ask the staff for assistance in booking anything. It's probably cheaper to go directly to the vendors which you can find near the shores or canals, or to make reservations via email.