there is only one piece of information you need to know which is you must book in advance, go without and you will be queueing for at least 2 hours where the pre book people walk passed you to the front of the queue and enter before you. Ignore the 100's of people offering queue jumping and tours its just a rip off! Obviously the reason you are going is to see the Sistine chapel but to get there you have to navigate the museums which can take at least an hour with the 1000's of other people trying to get to the main attraction. it is however worth the wait although its probably not what you are expecting, stunning all the same.
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