If you are in Rome with a Tour Group (e.g. TopDeck) - HIGHLY recommend doing the optional guided tour of the Vatican Museums. If you're a FIT traveller, then I highly recommend buying the tickets online together with a guided tour - you don't have to join the super long queue (take the short one).
We got a Tour Guide named Jill, and not only was she a Doctor of some sort - her knowledge of the history of Christianity/Catholicism was well grounded, her appreciation and knowledge of art was amazing, and all that plus her passion made the whole Vatican Museum Tour unbelievably special.
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