Stayed at the Hotel Borromeo - firstly conveniently situated about 300 meters from the main Bus and Train Station, and on the Tour Bus routes. Also in the heart of the Old City and all the tourist attractions.
The Receptionist was extremely patient and helpful - excellent. Gave us a map and explained/showed us all the places to see... (there are so many but he gave us the main ones)
We walked to and from most places, but also used a tour bus to get to the far side (Vatican) and then walked back past other attractions.More