I was so glad I stayed in Casa Sant'Anna! The area is not touristy at all, yet it's easy walking to the most of the attractions. Not mentioning the Colosseum that is withing 5-7 minutes walk (and you almost can see from the room :)) The lovely piazza with the fountain in front the Casa is so local and so vivid! You can get lost (in a good way) in all those little curling streets, alleys (vicolo) and stairs and discover some interesting buildings, cafes and artifacts. I felt very safe even getting back as late as after 11pm - the Casa has a curfew and they lock the front-door at 11 pm (winter) but each morning they give you a unique code for the door to get in after that.
My double room w/bathroom/shower on the 3d floor facing the piazza was basic, clean and comfortable with extra towels and blankets available. For breakfast they serve tea/coffee/juices/milk, corn-flakes and muesli, processed cheese, butter, few types of jams, pastry and rosetta-rolls. The breakfast was enough to last me for a good half a day (but I'm a light eater). There a coffee vending machine in the lobby.
The staff (nuns) is friendly and nice though it seems the lady at the reception doesn't speak much English. They give you a very good free map - it lasted me a week and I did use it extensively.
If you're like me and just need a clean safe place to sleep and prefer to spend most of the time exploring the city - the Casa is perfect! And if I'm ever again in Rome, Casa Sant'Anna would be my first choice to stay at.
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