Depending on where your hotel it, many of the city's attractions are within walking distance if you enjoy walking. Please note street signs on poles do not exist, but are part of the masonry of buildings if they are there at all. Streets change names often so consult your map.
A taxi ride from Termini Station (rail) to our hotel (5 minute ride) was 30 euros (about $45). An absolutely ridiculous price. We learned later that the subway, which was very efficient and I think 3 euros for both of us, went within a block of our hotel. If at all possible, find where your hotel is located in relation to the subway. We walked to the Vatican early in the morning, it took about 45 minutes, but decided in the heat to take the metro back which took about 10 minutes. There is a lot to see walking, but the metro gets you places fast on the cheap.
We used a hotel to airport taxi service, which was basically a newer Mercedes sedan with a chauffeur. He was at our hotel at 7AM as requested (actually early) and extremely professional. I felt a heck of a lot better about paying him 45 euros than a taxi their 40 euro charge for airport transport. We didn't want to miss our plane home and making special arrangements felt right. My wife heard a guy in the airport terminal saying to a co-traveller "that was the worst train ride of my life", which made me feel even better about the airport taxi service I ordered. Happy wife, happy life. Enjoy Rome. PS the sit-down restaurants are overpriced and the food was crappy. Much better value and food at some lower priced little take-out/eat-in places.
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