Don't even consider going to visit the Vatican and the Sistine Chapel without a tour guide. We met our wonderful tour guide Isabella around 9:00 AM and made our way right past the chumps in line who got there as early as 7 AM! Avoiding that long line is reason enough to go with a guide, but Isabella was also a wealth of knowledge on the Vatican and the Sistine Chapel. Her love for her home city and all it's history was infectious. Isabella was engaging, friendly and just fun to be around.