Have been to Rome before, but wanted to see Sistine Chapel and some of the other highlights.
The Chapel is overpowering, very crowded, with guards shushing everyone to keep quiet. In saying that it was really worth seeing, just a mass of paintings. Would have liked to be able to roam slowly to absorb the workmanship. The Vatican is a superb place with many great statues and other sites, must be in your bucket list.
Many people say Rome is too crowded, it is, but ignoring that, it has such a history, it is a must in your lifetime, but be prepared for a long tiring day, which is worth while