The museum is arranged by era, starting with the Renaissance, then Baroque, Classical, Biedermeier period, Romantic, End of the 19th Century, and 20th Century. Parts of it concentrate on Leipzig composers, instrument makers, and collectors. But it is much more than a local collection. The labels are only in German; some of the museum employees stationed in the rooms speak good English, some speak none. There are computer stations in each section where you can choose among 10 or so options to listen to a specific instrument. At the end there's a room where you can play instruments, and they have a great variety available.
I was amazed at the quality of the instruments the museum has acquired. Some gorgeous pianos. Wonderfully carved violins and other strings. Beautiful wooden wind instruments.