Visited here on a Friday morning, and it was fantastic. Spitalfields has been an active market since the 1600s, and the area was once home to Huguenot silk weavers (1600s)--and Irish weavers who followed in the 1700s. Lots of unique vendors and goods---and the surrounding area is chock full of great shopping and restaurants (Uniglo, Joseph Cheaney handmade shoes, Flying Tiger (Copenhagen), Anthropologie, and many unique gift stores). I especially liked the wares made by a unique handmade shoe craftsman and numerous vendors selling interesting (and cheap!) linen clothing. On the historic side of things, you can still see lovely houses in the area once inhabited by the silk weavers with brightly lit large glassed areas on the uppermost floors--where their weaving was done.
I returned on a Sunday afternoon, and the market was even busier (and more packed) with great vendors and great finds. If you like a different shopping experience in an interesting venue, this is a must do.