I recently stayed at the Holiday Inn while in Santo Domingo on business. I was skeptical of the hotel given it was a Holiday Inn branded hotel and from some of the reviews online. However, the hotel exceeded all of my expectations.
The rooms was tidy, modern and well designed. There is a great (but small) gym overlooking the pool and rooftop bar. You can enjoy a Presidente by the pool overlooking the city.
I ate all of my meals in the hotel restaurant, which offers a good wine list and varied menu. The hotel also has a nice cafe in the lobby and bar on the mezzanine floor.
This should be your first choice for a business hotel in Santo Domingo.More