Belize city to Hopkins, around 3 hours, depending on your driving. Driving is easy in Belize except I would not advise it at night. The Hopkins road is unpaved but reasonable, and it might even be paved by the time you get here.
The journey along the Hummingbird Highway which is most of the route, is very beautiful. Car hire is expensive, and gas is US$5.50 per gallon. If you hire a vehicle, you will need to get one with permission to go on unpaved roads.
If you find a good deal on a rental car, then go for it. The roads are fine, although many are not paved. If you're a confident driver, you shouldn't have any problems.
Just make sure you do NOT turn left at the first sign that reads "Dangriga/Hopkins" or you will end up on the Coastal road. Dirt road, boring, long, no views. Instead, follow road to Belmopan and proceed from the there, the drive along the Hummingbird HWY is stunning, take your time, and take your camera.
We just made that trip a few eeks ago. It is about 3 hours. (it only took us 2.5 hours going back but it is a 2 land road and you can get delayed by orange trucks or buses. The last 6 miles is a rough dirt road but the rest of the way was fine. I would recomend the car rental rather than a flight to Dangriga which is still a distance away and it helped to have a car in Hopkins. We rented from Crystal at the airport in Belize City. The cars are expensive but only a little more than flying 2 people and much cheaper than the flights for 4 people.
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