The Omni is very good + it's in a good location on the RW.
If you want a little more luxurious that is only a 5 min walk to main area then check out the Westin www.westin.com/riverwalk the room are a little larger as well.
If you want very luxurious then check out the Mokara www.mokarahotels.com they also have the best Spa. & on the quiet side of the Riverwalk just being a 5 min walk to main area.
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