I-276 is fine until you get to the Rte 1 and I-276 merge. Then it is a pain in the butt. I used to commute that way to Horsham.
Can't help with your other options.
But look at the traffic.com website for Philadelphia will give you a good idea what is happening on the roads every day.
Neither is good, but I'd be inclined to take. 276.
I do that exact run when I have to go into the office. 276 is your better bet generally, but check traffic as either route backs up at the drop of a hat.
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