Dayton isn't a huge airport, but it's served by most of the major airlines, so you should be able to find a flight. You will probably have to change planes, but that would likely be the case even if you flew out of a larger airport.
It is only about a four hour drive from Dayton to Kalamazoo, so when you factor in changing planes, needing to get to the airport early to get through security, etc., it will probably end up being quicker to just drive.
I agree with Cincy – driving may be your best option. Kalamazoo is not a large airport and from what I can tell Northwest is the only straight through flight from Dayton. Not worth the price of the airline ticket IMO. I would drive.
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