Is it easy access on and off 59 then to 49 south to Biloxi?
We just stayed there about a month ago. When you get off the interstate coming from the north then all you do is go across the bridge and turn at the first left. Go down to the stop sign and turn left again and you are right there. US 49 south is just about a mile down US 98 toward Hattiesburg- right beside the University of Southern Mississippi. We also went down to Biloxi and Gulfport when we visited. Not a lot on the road so get your gas and food in Hattiesburg or either wait until you reach the coast. It only took us about an hour and 15 minutes to drive it.
Have a nice trip.