Definitely take Highway 1 to get to Lompoc....it is a more direct route to Lompoc and the drive is much more scenic through rolling hills that are just starting to turn an emerald green from the first growth of spring.
Directions are 101 North which will take you through Santa Barbara then parallels the Pacific Ocean then bends inland at Gaviota. You will go through a tunnel and about 2 miles after it you will see the exit for Highway 1.
Enjoy your visit,
My husband sometimes runs the Valley of the Flowers half Marathon in Lompoc (lom-poke) in June. Lovely time of year. Coming from LA we drive the CA-1 heading north in the morning from SB to Lompoc as we to like it best. The drive is through farm and ranch land.
After the race we head home on CA 246. There are some vineyards and wineries on 246, and so if time allows and you want to make some stops, I'd choose that route. Other difference, it's flatter.
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