From downtown Santa Monica, you can use Santa Monica Big Blue Bus #20 (www.bigbluebus.com) to reach one of the stations for the Expo Line light rail train. Take the train towards the 7th street Metro Center. The train stops across the street from the museum - the correct stop for the science center is announced on the train's PA system. a taxi is probably going to be $55'ish each way.
Santa Monica is fairly large and we need your exact starting point. Where, exactly, are you staying? If it's the Travelodge or anything on that side of SM, the above directions won't help you at all.
We took the train recently. It is very, very convenient. I recommend you take the bus to the Culver City train station.
Here is the link to the Big Blue Bus (Santa Monica's system) so you can plug in your starting point and ending point in case leaving from downtown SM is not convenient for you:
Thanks so much for your help. I havent booked the accomodation yet so I am not sure what part of Santa monica we will be in. I will check out Big Blue Bus and the train network.
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