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San Hose or San Isidro?

Hello:

We have a choice (thru our timeshare company) of staying at EITHER Tera Villas Los Palmas in San Jose or at Hotel del Sur in San Isidro.

We plan on going to Manuel Antonio and doing other activities and excursions.

Which is the better base for that ? Or, which is the better/safer place to stay?

Thanks for any advice!