By Sandton, do you mean the Sandton Sun and Towers Hotel? If so, then I would say the Palazzo Intercontintental Hotel (adjacent to Monte Casino Entertainment complex) is nearest if you go via the highway.
Both hotels are in the area known as Sandton (large area) but the Sandton Sun and Towers is in the centre of Sandton whereas the Palazzo is in the Fourways area, but Fourways is an area within Sandton. Hope I'm not confusing you!
Coming from the airport, you would get onto the highway towards Pretoria and then once you come off at the William Nicol off-ramp the Palazzo is a couple of blocks off the highway. If you were staying at the Sandton Sun and Towers (also an Intercontinental by the way) then coming off the highway, it's about another 10kms or so towards the city centre (although nowhere near the centre of the city).
Hope this helps.
Thanks Gemini. Can you recommend a one night trip to Pilanesburg?
Regarding accomodation in Pilanesberg, I published some 'phone numbers few months back. I lost this booklet so I can't re-publish them. Try searching for "555" on this site, as I remember that it is a component of the 'phone number.
Re recommendation of one night in the Pilanesberg. It would depend on what time you get there.
If you get there (1.5 hours drive from the northern suburbs of Jhb) in the morning, then you've got the whole day to either drive yourself around the park or arrange for a guide ranger. If you get there later than that, then you've only got the evening.
So if you've only got one night, then go should still go for it - you may not see everything you'd like to, but you will still have the experience. And of course you may experience and see different animals at night than you would during the day.
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