When organising a trip through Tuscany in April, I found it tricky to think how to get myself (and family) sorted, and was grateful for advice.
For those in same position...we caught train from Rome to Chiusi, with minimum of fuss we walked very short distance across road to Hertz, where our brand new/ as ordered car was waiting for us. We based ourselves in Montepulciano and Lucca, and returned the car at Venice.
There was some advice at the time that Hertz was closing, but this was not the case.
My contact online and at the time of pick-up was Sergio, and I found him fantastic. A good experience.