By train, from Bruxelles-Nord, Bruxelles-central or Bruxelles-Midi. There are hardly any inter-city buses in Belgium and those there (e.g. Brugge-Ghent) take 4 times as long as trains because their purpose is to serve the towns and villages in between.
See www.belgianrail.be or, for timetables only, http://www.railtime.be/website/train-schedule - remembering that you have to use French/Dutch versions of station names, e.g. Brugge, Gent St. Pieters, Antwerpen-Centraal.
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