San Toma would be the nearest Vap stop - maybe 100 yards to walk, with a bridge or two.
San Toma is not that far as you say, but I have walked to Hotels in that area many times,
From the San Toma vap stop, walk until you hit a tee intersection - say 40 metres.
Turn left at the tee, onto Calle del Campaniel, go about 40 metres.
Turn right before you cross the bridge.
Turn left at the next bridge, Ponte Donna Onesta, continue down Calle Donna Onesta.
Take the next right, hotel is about 20 or 30 metres, and it is well marked.
I do know thee area quite well, but when you consider how long it takes to get to San Toma, the walk is not that bad,
It's less than half a mile from P Roma to Hotel Pantalon. You need only cross three bridges. Cross Rio Novo by Ponte Tre Ponti, cross Rio del Gaffaro by Ponte Gaffaro or by Ponte de Ca' Marcello, and follow your nose. [Not that there is a smell, I mean carry straight on.] Cross Rio di San Pantalon by Ponte Vinanti. It's as near to a straight line as you'll ever get in Venice.
You have the address wrong. It's Crosera San Pantalon, not Salizada San Pantalon, and it's 3941 not 3942 - not that that should make any difference. That's from the hotel's website.
Here is a map.
If you have luggage note there are at least three bridges to cross to get there.
Thanks for all that replied, will help a lot !!
Thanks for map
There is a slightly quicker way than Lynns Map, I stayed at hotel Pantalon a few years ago. Take the 3rd bridge to your right facing the canal, near Hotel Arlecchino on the map. cuts off about 5 mins.