I spent 4 days in Lille over xmas 2005, and I must say that unless you have access to a car (and therefore the countryside) you will struggle to spend a week in Lille. If you hire a car you can visit the WWi battlefields in Belgium (Ypers, etc) which are only a spit away
Brussels is closer to Lille, and would provide a good counterpoint/balance. I found Lille more like Belgium than France anyway
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