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Tip: For this 10-state trip allow at least 14 days; 21 will be more relaxed. To avoid northern snow (likely October-May) and southern humidity (June-September) road trip in two stages. Or do it all in late-summer and prepare for the heat.
Starting in the Upper Midwest and ending in the Deep South, this supremely scenic byway follows the meandering Mississippi from the lakes of Minnesota via the Delta to Louisiana’s swamps. It reveals a storied past of ancient peoples, Civil Rights and the Civil War. Expect the blues on your radio, high bluffs in your windshield, home-cooking on your table and – always - Old Man River by your side.