We noticed that you're using an unsupported browser. The TripAdvisor website may not display properly.
We support the following browsers:
Windows: Internet Explorer, Mozilla Firefox, Google Chrome. Mac: Safari.
The latest reviews. The lowest prices. The perfect place to shop for hotels.

Hotels near Santee National Wildlife Refuge

  • Sort by:
  • Traveler Ranked
  • Lowest Price
  • Distance
TripAdvisor members only.
Login for exclusive access to hotel deals up to 40% off
Login to get best prices
Sponsored
9060 Old #6 Highway, Santee, SC 29142
4.4 miles from Santee National Wildlife Refuge

The price you found is 14% lower than this hotel's average rate of $132/night.

We analyze rates over a 60 day period, and compare your selection to the average rate of comparable stays to ensure you're getting the best possible deal.

Top Deal
$134*
$114* /night
View Deal
Hampton.com
$134*
Hotels.com
$114*
Hotwire.com
$114*
I-95 & US Highway 301 South, Santee, SC 29142
4.0 miles from Santee National Wildlife Refuge
No photo provided
8929 Old Number Six Highway, Santee, SC 29142
4.2 miles from Santee National Wildlife Refuge
$82* /night
View Deal
Booking.com
$82*
QualityInn
$82*
Hotwire.com
$82*
9125 Old Hwy 6, I-95 Exit 98 - Hwy 6 East, Santee, SC 29142
4.3 miles from Santee National Wildlife Refuge
Top Deal
$80*
$55* /night
View Deal
Expedia.com
$55*
Travelocity
$55*
HotelQuickly
$80*
9091 Old Hwy 6, I-95 Exit 98, Santee, SC 29142
4.3 miles from Santee National Wildlife Refuge
Top Deal
$55*
$50* /night
View Deal
Expedia.com
$55*
Orbitz.com
$55*
Hotwire.com
$55*
9117 Old Number Six Hwy, Santee, SC 29142-8899
4.3 miles from Santee National Wildlife Refuge
Top Deal
$57*
$51* /night
View Deal
Expedia.com
$51*
Hotwire.com
$51*
getaroom.com
$57*
9112 Old # 6 Highway, Santee, SC 29142
4.3 miles from Santee National Wildlife Refuge
$51* /night
View Deal
Expedia.com
$51*
Orbitz.com
$51*
Hotwire.com
$51*
9060 Old #6 Highway, Santee, SC 29142
4.4 miles from Santee National Wildlife Refuge

The price you found is 14% lower than this hotel's average rate of $132/night.

We analyze rates over a 60 day period, and compare your selection to the average rate of comparable stays to ensure you're getting the best possible deal.

Top Deal
$134*
$114* /night
View Deal
Hampton.com
$134*
Hotels.com
$114*
Hotwire.com
$114*
139 Bradford Blvd, Santee, SC 29142
4.4 miles from Santee National Wildlife Refuge
Top Deal
$158*
$116* /night
View Deal
Booking.com
$116*
HolidayInn.com
$116*
HotelQuickly
$158*
114 Bradford Blvd, Santee, SC 29142-8931
4.4 miles from Santee National Wildlife Refuge
221 Britain Street, Santee, SC 29142
4.4 miles from Santee National Wildlife Refuge
Top Deal
$132*
$98* /night
View Deal
Booking.com
$98*
ComfortInn
$98*
HotelQuickly
$132*
628 Bass Dr, Santee, SC 29142-8986
4.4 miles from Santee National Wildlife Refuge
249 Britain St., Santee, SC 29142
4.4 miles from Santee National Wildlife Refuge
Top Deal
$59*
$51* /night
View Deal
Booking.com
$59*
Hotels.com
$51*
Travelocity
$51*
400 Buff Blvd, I-95 Exit 108 West Side of Intersection, Summerton, SC 29148-7400
5.7 miles from Santee National Wildlife Refuge
#1 of 2 hotels in Summerton
Top Deal
$83*
$57* /night
View Deal
Priceline
$57*
TripAdvisor
$57*
HotelQuickly
$83*
Interstate 95, Exit 98, P.O. Box 188, Santee, SC 29142
5.9 miles from Santee National Wildlife Refuge
$99* /night
View Deal
Expedia.com
$99*
Hotwire.com
$99*
Priceline
$99*
2 Buff Boulevard, I-95, Exit 108, Summerton, SC 29148
6.1 miles from Santee National Wildlife Refuge
#2 of 2 hotels in Summerton
5932 Alex Hwy, Manning, SC 29102
11.5 miles from Santee National Wildlife Refuge
Top Deal
$51*
$48* /night
View Deal
Booking.com
$51*
Expedia.com
$51*
Hotwire.com
$51*
2284 Raccoon Road, I-95 Exit #119, Manning, SC 29102
15.8 miles from Santee National Wildlife Refuge
$71* /night
View Deal
Booking.com
$71*
Travelocity
$71*
Priceline
$71*
3031 Paxville Hwy, Manning, SC 29102-6449
15.8 miles from Santee National Wildlife Refuge
Top Deal
$98*
$68* /night
View Deal
Booking.com
$68*
Hotwire.com
$68*
HotelQuickly
$98*
2825 Paxville Hwy, Manning, SC 29102-6447
15.8 miles from Santee National Wildlife Refuge
Top Deal
$77*
$58* /night
View Deal
Expedia.com
$58*
Hotwire.com
$58*
HotelQuickly
$77*
I-95 & US Highway 378, Turbeville, SC 29162
15.8 miles from Santee National Wildlife Refuge
No photo provided
2822 Paxville Hwy, Manning, SC 29102-6446
15.9 miles from Santee National Wildlife Refuge
Top Deal
$135*
$110* /night
View Deal
Hampton.com
$110*
Expedia.com
$110*
HotelQuickly
$135*
1062 Cross Road, Manning, SC 29102
15.9 miles from Santee National Wildlife Refuge
Top Deal
$66*
$54* /night
View Deal
Hotwire.com
$54*
Travelocity
$54*
HotelQuickly
$66*
2816 Paxville Hwy, I-95 - Exit 119 and Hwy 261, Manning, SC 29102-6446
16.0 miles from Santee National Wildlife Refuge
Top Deal
$80*
$65* /night
View Deal
Orbitz.com
$65*
Priceline
$65*
HotelQuickly
$80*
3402 Five Chop Rd, I-26 Exit 154B HWY 301, Orangeburg, SC 29115-9670
17.9 miles from Santee National Wildlife Refuge
Top Deal
$77*
$55* /night
View Deal
Travelocity
$55*
Booking.com
$55*
HotelQuickly
$77*
111 Conners Dr, Saint George, SC 29477-8968
20.0 miles from Santee National Wildlife Refuge
Top Deal
$58*
$50* /night
View Deal
Expedia.com
$58*
Hotwire.com
$58*
Hotels.com
$58*
663 Citadel Rd, Orangeburg, SC 29118-9720
22.5 miles from Santee National Wildlife Refuge
$110* /night
View Deal
Expedia.com
$110*
Orbitz.com
$110*
Priceline
$110*
749 Citadel Rd, Orangeburg, SC 29118-9705
22.6 miles from Santee National Wildlife Refuge
$144* /night
View Deal
Hampton.com
$144*
Expedia.com
$144*
Hotwire.com
$144*
731 Citadel Road, Orangeburg, SC 29118
22.6 miles from Santee National Wildlife Refuge
$98* /night
View Deal
Expedia.com
$98*
Hotels.com
$98*
Country Inns
$98*
746 Citadel Rd, Orangeburg, SC 29118-9704
22.7 miles from Santee National Wildlife Refuge
Top Deal
$106*
$83* /night
View Deal
Hotwire.com
$83*
Expedia.com
$83*
getaroom.com
$106*
118 Sleep Inn Road, Exit #145-A off I-26, Orangeburg, SC 29118
22.7 miles from Santee National Wildlife Refuge

The price you found is 14% lower than this hotel's average rate of $119/night.

We analyze rates over a 60 day period, and compare your selection to the average rate of comparable stays to ensure you're getting the best possible deal.

Top Deal
$140*
$102* /night
View Deal
Orbitz.com
$102*
Expedia.com
$102*
HotelQuickly
$140*
Still looking for a place to stay?
Summerton has 1 B&Bs/inns with 3 reviews
18 Buff Blvd, Summerton, SC 29148-9448
6.0 miles from Santee National Wildlife Refuge
#1 of 1 Summerton B&B and Inns
See all 1 Summerton B&Bs/inns
See all hotels in or near Summerton
2284 Raccoon Road, I-95 Exit #119, Manning, SC 29102
15.8 miles from Santee National Wildlife Refuge
$71* /night
View Deal
Booking.com
$71*
Travelocity
$71*
Priceline
$71*
3031 Paxville Hwy, Manning, SC 29102-6449
15.8 miles from Santee National Wildlife Refuge
Top Deal
$98*
$68* /night
View Deal
Booking.com
$68*
Hotwire.com
$68*
HotelQuickly
$98*
1062 Cross Road, Manning, SC 29102
15.9 miles from Santee National Wildlife Refuge
Top Deal
$66*
$54* /night
View Deal
Hotwire.com
$54*
Travelocity
$54*
HotelQuickly
$66*