Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighborhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travelers say that Istanbul isn’t just one city, but many cities within one.

Even if you’ve never been to this Cyclades island in the Aegean Sea, you’d still recognize it immediately – candy-colored houses carved into cliffs, sapphire waters, gleaming white buildings topped with half-spheres the color of a stormy sky. Here you’ll find peace as you roam the black sand beaches or the streets of a provincial village like Imerovigli. Beautiful Oia is world famous for its sunsets, which seem tinted with every shade of an artist’s palette.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Walk the Freedom Trail the first time you visit Boston and you'll quickly get a sense of this coastal city's revolutionary spirit and history. But make sure you also explore some of Boston's fine museums (try the Isabella Stewart Gardner, featuring masterpieces displayed in their collector's mansion) and old neighborhoods (like the North End, Boston's Little Italy). You can't claim to have experienced real Boston culture, though, until you've watched a Red Sox game from the bleachers.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Whether rocking out to music legends inside the Rock and Roll Hall of Fame or viewing Monets and Picassos at the Cleveland Museum of Art, Cleveland is a city that mixes equal parts grit and sophistication. Nosh award-winning food in historic buildings, tip back some craft beers amid a Lake Erie beach party or cheer on a championship team with a hardball of locally distilled spirits. All in Cleveland.

Discover an essential chapter of America's history in the cobblestone streets, river walks and monuments of Richmond. Originally a colonial settlement, Virginia's capital is now a thriving hub for culture, shopping and outdoor fun. Explore Civil War history at the American Civil War Museum, stroll along the canal downtown or test your nerve whitewater rafting on the James River. With lively neighborhoods and a vibrant restaurant scene, Richmond is perfect for a quick break or an extended getaway.

Ohio’s capital city is full of beautiful neighborhoods, a critically acclaimed food scene and top-ranked attractions. This creative-minded destination offers something for everyone. Families will enjoy COSI, the nationally known science center, as well as the Columbus zoo and its neighboring water park. Art lovers will savor the collections at the Columbus Museum of Art and revel in Gallery Hop, a monthly celebration in the Short North Art District. Columbus is a city that invites exploration.

Perfectly positioned at the westernmost tip of sparkling blue Lake Superior, Duluth offers visitors a true escape from the stresses of everyday life and an opportunity to enjoy nature. You can opt for a more leisurely pace: spending time at one of the city's 23 beautiful parks, taking an unhurried drive along the scenic North Shore, bird watching at Hawk Ridge, skipping stones on the Lake with the kids. Or go for a more structured itinerary: the aquarium in the morning, lunch at a sumptuous restaurant on the waterfront plus a tour of the famous Sculpture Walk, then a visit to the historic Railroad Depot in the afternoon. Either way, you are sure to leave Duluth feeling relaxed and refreshed.