Over the centuries, many cultures have added their mark to this prized piece of land. Today, you can experience those influences firsthand by exploring Istanbul’s mahalles (neighborhoods). From the holy sites of Sultanahmet and the 19th-century European elegance of Beyoğlu to the high fashion of Nişantaşı, the vibrant café society of Kadıköy and the football-loving streets of Beşiktaş, it’s easy to see why travelers say that Istanbul isn’t just one city, but many cities within one.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

Tallinn's atmospheric Old Town is an enthralling hodgepodge of medieval streets and spires. It's a small city, and the tourist areas are safe and easily explored on foot. Buy a Tallinn Card if intending to use buses, trolleys or trams. For a look into Tallinn's past, visit Rocca-al-Mare Open Air Museum's typical rural Estonian taverns, windmills and watermills, see the onion-domed 1900 cathedral or join the bustle in historic Town Hall Square. St. Olav's spire was once the tallest in the world.

The bohemian allure and fairytale features of Prague make it a perfect destination for beach-weary vacationers who want to immerse themselves in culture. You could devote an entire day to exploring Prazsky hrad (Prague Castle), then refueling over a hearty dinner at a classic Czech tavern. Spend some time wandering the Old Town Square before heading over to gape at The Old Town Hall and Astronomical Clock. Prague’s best bars are found in cellars, where historic pubs set the scene for a night of traditional tippling.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Munich exudes Bavarian charm. Beer fanatics should head immediately to the Hofbräuhaus, a hops heaven that’s been churning out the good stuff since 1589. The drinking is downright legendary during Oktoberfest, a celebration of local beers and German specialty foods. Emulate world-class athletes at the Olympiapark, where skating on the Olympic ice rink will make you feel like a champion. The promenade of Marienplatz is perfect for people watching and gawking at the Glockenspiele of City Hall.

The majestic Austrian Alps stretch across the country, an awe-striking area of Ice Age valleys, verdant heaths and alluvial cones within Europe's largest national park, 700-square-mile Hohe Tauern. Taking in the dramatic cities of Salzburg and Innsbruck and the beautiful province of Tirol, home to spectacular skiing and hiking, as well as Gross Glockner, Austria's highest peak, and some of the world's best winter and summer sports playgrounds, the Austrian Alps are an outdoor lover's paradise.

Golden palaces, floating markets, majestic porcelain-laid spires…you've never seen a capital city quite like Bangkok. Visit Pratunam or Siam Square for premium shopping, then unwind in the European-style gardens of Dusit. Thon Buri is home to the awesome Wat Arun temple, and over in Phra Nakhon, you’ll find the Wat Pho temple of the Reclining Buddha. Savor mango sticky rice at a food stall before taking in the gilded splendor of the Grand Palace.